This position will contribute to Client's drug discovery and clinical development efforts in the Transporter Science Group within the Department of Pharmacokinetics, Pharmacodynamics Drug Metabolism, and Bioanalytics (PDMB) at Client Research Laboratories in West Point, PA.
• The main goal of this group is to develop and execute assays that will predict the disposition of drug candidates and provide insights into the potential for drug-drug interactions by being a substrate or inhibitor of drug metabolizing transporters.
• Successful candidates should have a passion for generating high quality in vitro data for use by project teams across a range of therapeutic areas and must have independent bench level skills for working with a range of in vitro assay systems as well as the capacity to contribute to complex research projects.
• Candidates must have demonstrated leadership as well as excellent written and verbal communication skills.
Quals--
Education Minimum Requirement:
• Master’s degree in a relevant field (e.g. Biochemistry, Biology, Biotechnology, Molecular and Cell Biology, Pharmacology; Pharmaceutical Sciences) with 0-3+ years relevant experience
• Bachelor’s degree in a relevant field (see above) with 5+ years relevant experience
Required Experience and Skills:
• Cell culture, including routine maintenance using aseptic cell culture technique and ability to perform experiments per established protocols
• Track record of working collaboratively in a team environment delivering results for complex in-vitro biological systems
• Data analysis and interpretation using tools such as Excel, Graphpad PRISM, ability to document results
• Autonomy, attention to detail, critical thinking, growth mindset
Preferred Experience and Skills:
• Experience conducting in-vitro drug transporter or metabolism studies such as substrate phenotyping and inhibition assays in recombinant cell lines, vesicles and primary hepatocytes or comparable cell-based systems.
• Experience with automation and/or developing complex liquid handling methodologies for in vitro experiments
• Basic understanding of quantitation using radiometric or LC/MS methods
Personality:
• Open minded
• Team player
• Adaptability
• Flexible
• Quick learner
• Detail oriented
• Good organization skills
Note:
• 1year assignment with possibility of an extension.
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