Job Description

About Enlaza Therapeutics  

Enlaza Therapeutics is pioneering a disruptive new class of biologic drugs called War-Locks. Unlike traditional protein therapeutics, War-Locks are uniquely engineered to bind specifically and irreversibly to disease-related targets. We are committed to developing these innovative therapies to help patients battling cancer and other serious illnesses. 

Role Description  

Enlaza Therapeutics’ New Technologies team is seeking a highly motivated Scientist I with expertise in protein-protein interactions, alongside experience in molecular biology, protein engineering, and protein production. The ideal candidate is a highly motivated individual with extensive hands-on experience and a deep theoretical understanding of the quantitative characterization of antibody binding. This person will help steer the development of new therapeutic concepts and applications. The ideal candidate should: 

1. possess strong scientific rigor, creativity, and problem-solving skills 
2. be proficient in independently designing and executing experiments 
3. have excellent communication, documentation, and organizational skills 
4. be eager to expand their skill set in a fast-paced, collaborative research environment 

This laboratory-focused position offers an exceptional opportunity to work with a driven team committed to excellence while interfacing directly with multiple research groups, including biotherapeutic discovery, platform engineering, protein sciences, pharmacology, and leadership.

Key Responsibilities  

• Design, execute, and interpret protein-protein interaction and kinetic binding assays using Bio-Layer Interferometry (BLI) 
• Serve as the subject matter expert for BLI and establish rigorous, quantitative guidelines for evaluating binding kinetics, affinity, and assay quality. 
• Optimize BLI experimental conditions, including buffer systems, immobilization strategies, and analyte concentrations for robust and reproducible results 
• Maintain and calibrate BLI instrumentation and help implement best practices across the team 
• Utilize molecular biology and protein engineering knowledge to design novel multifunctional antibodies 
• Express and purify (using affinity, ion exchange, size exclusion, and other chromatographic methods) protein candidates with high quality and purity specifications; operate lab-scale systems such as ÄKTA 
• Perform routine protein analysis techniques such as ELISA, SDS-PAGE, and Western blotting 
• Coordinate antibody characterization workflows, including sample submission for LC-MS, analytical SEC, and functional cell assays; analyze, organize, and present resulting data 
• Lead and prioritize multiple concurrent research activities with minimal supervision 
• Maintain thorough, accurate, and timely documentation of experiments in an electronic laboratory notebook (ELN), adhering to internal protocols and regulatory standards
• Clearly and effectively communicate experimental plans, progress, and findings to supervisors, cross-functional teams, and company-wide audiences through reports and presentations 
• Proactively track emerging developments in protein chemistry, synthetic biology, and related disciplines, and leverage cutting-edge technologies to fuel innovation 

Required Qualifications  

• Ph.D. in Biology, Biochemistry, Biological Engineering, Chemical Biology, Chemical Engineering, Immunology, or related scientific discipline 
• Minimum of 0 - 2 years related experience; may include post-doctoral experience 
• Highly collaborative with strong written and verbal communication abilities 
• Comfortable working in a dynamic, fast-paced, cross-functional team setting
• Excellent organizational and time-management skills; able to prioritize and manage multiple projects concurrently 

Desired Knowledge and Experiences  

• Demonstrated and extensive hands-on experience in BLI assay setup, development, execution, and data analysis 
• Deep theoretical understanding of key concepts in protein-protein interactions, including affinity, kinetics, valency, selectivity, epitope mapping, thermodynamics, and binding models 
• Familiarity with protein engineering techniques, including mutagenesis, affinity maturation, or humanization 
• Skilled in a range of modern molecular biology techniques, including vector design, PCR, site-directed mutagenesis, gel extraction, restriction cloning, Gibson Assembly, Golden Gate Assembly, and plasmid preparation 
• Strong background in recombinant protein production and purification from E. coli and/or mammalian systems; familiarity with laboratory-scale purification chromatography platforms such as ÄKTA 
• Competent in data analysis and interpretation using tools like Excel, Prism, JMP, Geneious, SnapGene, PyMOL, and Benchling; familiarity with MOE and FlowJo is a plus 
• Experienced in standard protein characterization methods such as ELISA, SDS-PAGE, and Western blotting 
• Familiarity with LC-MS-based characterization and analytical SEC 
• Prior exposure to engineered protein binders (e.g., antibodies, nanobodies/VHHs, DARPins) 

Compensation:  

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. 

Job Type:  

Full-time 

Supplemental Pay Types:  

Bonus pay 

Benefits:  

• 401(k) 
• Dental insurance 
• Employee assistance program 
• Flexible schedule 
• Flexible spending account 
• Health insurance 
• Flexible vacation
• Paid holidays
• Life insurance 
• Paid time off 
• Parental leave 
• Retirement plan 
• Vision insurance 

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